D. A. Gerasimenko, I. S. Shpagin, I. I. Novikova, O. N. Gerasimenko, A. M. Gorobey
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Novosibirsk Research Institute of Hygiene of the Federal Service for Supervision of Human Welfare, Novosibirsk, Russian Federation
Comparative characteristics of exacerbations of chronic obstructive pulmonary disease from exposure to harmful production factors in the content of tobacco smoking prevention at school
Abstract. To study the characteristics and predictors of exacerbation of COPD under the influence of various industrial factors. A total of 153 patients with occupational COPD (toxic gases and inorganic dust) were examined. The comparison group consisted of 103 patients with smoking COPD. COPD was diagnosed in accordance with the GOLD 2011 criteria. The duration of the study was 4. 9 ± 0. 25 years. All patients underwent a complex of clinical and laboratory studies with an emphasis on clinical characteristics and predictors of COPD exacerbation and lung function. The critical level of significance is p = 0. 05. The development of occupational COPD in the presence of toxic gases or inorganic dust affects the frequency and predominant phenotype of exacerbations. COPD from the action of toxic gases is characterized by rare but severe exacerbations, mainly with an eosinophilic type of inflammation, which respond well to therapy with systemic corticosteroids. COPD from dust is characterized by short-term exacerbations with a neutrophilic type of inflammation that do not require hospitalization, which respond well to therapy with bronchodilators; a significant proportion of exacerbations require the use of antibiotic therapy. Also, in COPD from the action of toxic gases, the experience of exposure to aerosols and gases of the working environment is among the independent predictors of any exacerbations, when, as from the action of dust, the significance of the experience and the intensity of exposure to dust has not been established. Thus, the revealed relationship will allow to optimize the tactics of diagnosis and treatment of exacerbation of COPD under the influence of various industrial factors.
Keywords: occupational chronic obstructive pulmonary disease, optimization, impact, production factors, predictor, exacerbation.
Paper submitted: May 25, 2021.
For citation: Gerasimenko D. A., Shpagin I. S., Novikova I. I., Gerasimenko O. N., Gorobey A. M. (2021) Comparative characteristics of exacerbations of chronic obstructive pulmonary disease from exposure to harmful production factors in the content of tobacco smoking prevention at school. The Science of Person: Humanitarian Researches, vol. 15, no. 2, pp. 177–185. DOI: 10. 17238/issn1998-5320.2021.15.2.22.
