L. A. Shpagina, D. A. Gerasimenko, I. I. Novikova, O. N. Gerasimenko, A. M. Gorobey
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Novosibirsk Research Institute of Hygiene of the Federal Service for Supervision of Human Welfare, Novosibirsk, Russian Federation
Risk models of exacerbations of chronic obstructive pulmonary disease of occupational genesis as a preventive element in the system of vocational guidance
Abstract. To study the optimization of diagnostics of exacerbation of COPD under conditions of exposure to various industrial aerosols. A single-center prospective cohort observational study of patients (156 patients) with various etiology of occupational COPD (toxic gases and inorganic dust) was carried out. The comparison group consisted of patients with COPD, the cause of which was tobacco smoking (103 patients). The control group was conventionally healthy individuals (99 people). Patients were diagnosed and treated in accordance with the latest clinical guidelines. The observation period was (4. 9 ± 0. 25) years. The most significant molecular markers of occupational COPD from the action of toxic gases from among the components of the endotype of the disease were serum concentrations of VEGF A and TGFβ1. Thus, the developed models will make it possible to optimize the diagnosis of exacerbation of COPD under conditions of exposure to industrial aerosols. Since the cellular and molecular components of inflammation are participants in many biological processes and their concentration, in addition to professional COPD, is influenced by many factors, it is rational to evaluate not one indicator as a marker, but to determine their combination characteristic of the predicted state.
Keywords: occupational chronic obstructive pulmonary disease, optimization, exposure, industrial aerosols, endotype, survival.
Paper submitted: May 25, 2021.
For citation: Shpagina L. A., Gerasimenko D. A., Novikova I. I., Gerasimenko O. N., Gorobey A. M. (2021) Risk models of exacerbations of chronic obstructive pulmonary disease of occupational genesis as a preventive element in the system of vocational guidance. The Science of Person: Humanitarian Researches, vol. 15, no. 2, pp. 138–144. DOI: 10.17238 /issn1998- 5320.2021.15.2.17.
